Cary Grant (Mortimer Brewster) ● Josephine Hull (Aunt Abby Brewster) ● Jean Adair (Aunt Martha Brewster) ● Raymond Massey (Jonathan Brewster) ● Peter Lorre (Dr. Einstein) ● Priscilla Lane (Elaine Harper / Elaine Brewster) ● John Alexander (Theodore 'Teddy Roosevelt' Brewster) ● Jack Carson (Officer Patrick 'Pat' O'Hara) ● John Ridgely (Officer Saunders) ● Edward McNamara (Police Sergeant Brophy) ● James Gleason (Captain Rooney) ● Grant Mitchell (Reverend Harper) ● Edward Everett Horton (Mr. Witherspoon) ● Vaughan Glaser (Judge Cullman) ● Chester Clute (Dr. Gilchrist)